957138-36-2Relevant academic research and scientific papers
3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase
Kumar, Dange V.,Rai, Roopa,Brameld, Ken A.,Riggs, Jennifer,Somoza, John R.,Rajagopalan, Ravi,Janc, James W.,Xia, Yu M.,Ton, Tony L.,Hu, Huiyong,Lehoux, Isabelle,Ho, Joseph D.,Young, Wendy B.,Hart, Barry,Green, Michael J.
scheme or table, p. 300 - 304 (2012/02/04)
The discovery and optimization of a novel class of quinolone small-molecules that inhibit NS5B polymerase, a key enzyme of the HCV viral life-cycle, is described. Our research led to the replacement of a hydrolytically labile ester functionality with bio-
ANTIVIRAL AGENTS
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Page/Page column 98; 99, (2010/11/29)
Compounds are provided having utility for the treatment of viral infections, particularly HCV.
