95716-20-4

Upstream product

• 95716-19-1 N-(tert-butyloxycarbonyl)-L-leucyl-L-phenylalanyl-L-proline benzyl ester 
• 70462-58-7 benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-prolinate 
• 41324-66-7 H-Pro-OBzl 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 51644-77-0 H-Phe-Pro-OBzl 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 

Downstream Products

• 96935-68-1 H-D-Val-Orn(Z)-Leu-Phe-Pro-OH_.HCl 
• 96935-56-7 Boc-D-Val-Orn(Z)-Leu-Phe-Pro-OBzl 
• 96935-58-9 Boc-D-Val-Orn(Z)-Leu-Phe-Pro-OH 
• 96935-57-8 Boc-D-Val-Orn(Z)-Leu-Phe-Pro-NHNH₂ 
• 95727-69-8 C₆₆H₈₁Cl₂N₇O₁₂ 
• 78834-34-1 C₆₆H₈₃N₇O₁₂ 
• 95727-70-1 C₅₉H₇₇Cl₂N₉O₁₁ 
• 78834-35-2 C₅₉H₇₉N₉O₁₁ 
• 95783-01-0 (S)-1-((S)-2-{(S)-2-[(S)-5-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-pentanoylamino]-4-methyl-pentanoylamino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester 
• 95716-23-7 (S)-1-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-5-benzyloxycarbonylamino-pentanoylamino]-4-methyl-pentanoylamino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester 
• 95727-71-2 C₅₉H₇₅Cl₂N₇O₁₂ 
• 78834-37-4 (S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 
• 95716-22-6 Orn(Z)-Leu-Phe-Pro-Obzl 
• 119351-79-0 (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Conformation and Complexation of a Cyclic Dodecapeptide with Alkaline Earth Metal Ions in Acetonitrile

The cyclic dodecapeptide, cyclo(L-Leu-L-Phe-L-Pro)4, was synthesized, and its conformation and complexation with metal ions in acetonitrile were investigated by c.d. and n.m.r. spectroscopy.Cyclo(L-Leu-L-Phe-L-Pro)4 was found to complex selectively with alkaline earth metal ions.The binding constant of the dodecapeptide with Ba2+ was larger than that of the cyclic hexapeptide, cyclo(L-Leu-L-Phe-L-Pro)2.In the free state, the skeletal conformation of the cyclic dodecapeptide ic non-symmetrical.When complexed with Ba2+, the conformation changes to a C4-symmetrical one having all peptide bonds in a trans configuration and four β-turn structures containing transannular hydrogen bonds.Formation of hydrogen bonds on complexation with the cation accounts for the large binding constant of the cyclic dodecapeptide.

Studies on peptide antibiotic 'gratisin'

According to a primary structure proposed for an antibiotic peptide, gratisin, four peptides containing respectively partial sequences, L-Phe-L-Pro-L-Tyr, D-Phe-L-Pro-L-Tyr, L-Phe-L-Pro-D-Tyr, and D-Phe-L-Pro-D-Tyr, were synthesized by a liquid phase meth