95716-72-6Relevant articles and documents
A new approach to the furan degradation problem involving ozonolysis of the trans-enedione and its use in a cost-effective synthesis of eplerenone
Pearlman, Bruce A.,Padilla, Amphlett G.,Hach, John T.,Havens, Jeffrey L.,Pillai, Muniraj D.
, p. 2111 - 2113 (2007/10/03)
Whereas ozonization of furan 3a affords little or no carboxylic acid 5, ozonization of the corresponding trans-enedione 6 afforded carboxylic acid 5 in 82.4% yield (cryst., overall from furan, 100 g scale; after workup with dimethyl sulfide, followed by mildly basic hydrogen peroxide). This new approach to furan degradation is showcased in a cost-effective synthesis of eplerenone, an important new medicine for cardiovascular indications.
