957194-91-1 Usage
General Description
1-(5-chloro-2-(trifluoroMethyl)benzyl)-7-(6-(4-Methylpiperazin-1-yl)pyridin-3-yl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine is a chemical compound with a complex molecular structure. It contains a benzyl group with a chlorine substitution and a trifluoromethyl group attached to a benzene ring, as well as a pyrido[2,3-b]pyrazine core with additional pyridine and piperazine moieties. 1-(5-chloro-2-(trifluoroMethyl)benzyl)-7-(6-(4-Methylpiperazin-1-yl)pyridin-3-yl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine likely has pharmaceutical applications due to its heterocyclic structure and potentially important biological activities. However, further research is needed to fully understand its properties and potential uses.
Check Digit Verification of cas no
The CAS Registry Mumber 957194-91-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,7,1,9 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 957194-91:
(8*9)+(7*5)+(6*7)+(5*1)+(4*9)+(3*4)+(2*9)+(1*1)=221
221 % 10 = 1
So 957194-91-1 is a valid CAS Registry Number.
957194-91-1Relevant articles and documents
Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase
Milkiewicz, Karen L.,Weinberg, Linda R.,Albom, Mark S.,Angeles, Thelma S.,Cheng, Mangeng,Ghose, Arup K.,Roemmele, Renee C.,Theroff, Jay P.,Underiner, Ted L.,Zificsak, Craig A.,Dorsey, Bruce D.
experimental part, p. 4351 - 4362 (2010/09/12)
Dysregulation of the anaplastic lymphoma kinase (ALK) is implicated in a variety of cancers. A series of tetrahydropyrido[2,3-b]pyrazines was constructed as ring-constrained analogs of a known aminopyridine kinase scaffold. Chemistry was developed to rapidly elaborate the SAR, structural elements impacting ALK inhibitory activity were exploited, and kinase selective analogs were identified that inhibit ALK with IC50 values ～10 nM (enzyme) and ～150 nM (cell).
