957206-56-3Relevant academic research and scientific papers
Synthesis of the proposed structure of queenslandon
Navickas, Vaidotas,Maier, Martin E.
supporting information; scheme or table, p. 94 - 101 (2010/03/03)
The proposed structure of the benzolactone queenslandon (6) was synthesized utilizing a triol containing building block prepared from d-ribose. While a ring-closing metathesis approach did not lead to the macrocycle, alkylation of a benzyl(phenyl)selane, elimination to generate the styrene double bond, followed by Mitsunobu macrolactonization proved to be successful. Spectral data suggest that the structure of queenslandon should be revised, probably to the C11 epimer.
Compositions And Methods Comprising Analogues Of Radicicol A
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Page/Page column 43-44, (2010/09/18)
Disclosed are novel analogues of the natural product radicicol A of formulae I, .Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the tre
Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors
Dakas, Pierre-Yves,Barluenga, Sofia,Totzke, Frank,Zirrgiebel, Ute,Winssinger, Nicolas
, p. 6899 - 6902 (2008/09/18)
(Chemical Equation Presented) Short and sweet: A concise and modular synthesis of radicicol A and related resorcylic acid lactones using fluorous isolation technology and immobilized reagents is reported (see scheme, R F = C3H6
