957212-64-5

Upstream product

• 957211-46-0 5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline 
• 957212-63-4 (E)-3-(2-bromo-6nitrophenyl)-1-[3-(1,1,2,2-tetrafluoroethoxy)-phenyl]-propenone 

Downstream Products

• 957212-74-7 5-(4-chloro-3-ethyl-phenoxy)-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-quinoline 
• 957212-76-9 5-(2,3-dichloro-phenoxy)-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-quinoline 

Relevant academic research and scientific papers

Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform

Tetrahydroquinoline A is a potent inhibitor of the cholesterol ester transfer protein (CETP), a target for the treatment of low HDL-C and atherosclerosis. Low HDL-C has been identified as a key risk factor for cardiovascular disease in addition to high LD

1,2,3,4-TETRAHYDRO-QUINOLINE DERIVATIVES AS CETP INHIBITORS

The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.