957272-64-9

Basic information

• Product Name: 2',4'-di-(2-methylpropanoyloxy)-acetophenone
• Synonyms: 2',4'-di-(2-methylpropanoyloxy)-acetophenone
• CAS NO: 957272-64-9
• Molecular Weight: 292.332
• Mol File: 957272-64-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2',4'-di-(2-methylpropanoyloxy)-acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-di-(2-methylpropanoyloxy)-acetophenone(957272-64-9)
• EPA Substance Registry System: 2',4'-di-(2-methylpropanoyloxy)-acetophenone(957272-64-9)

Safety Data

• Hazardous Substances Data: 957272-64-9(Hazardous Substances Data)

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 79-30-1 isobutyryl chloride 

Relevant articles and documents

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2

Human lipoxygenase (hLO) isozymes have been implicated in a number of disease states and have attracted much attention with respect to their inhibition. One class of inhibitors, the flavonoids, have been shown to be potent lipoxygenase inhibitors but their study has been restricted to those compounds found in nature, which have limited structural variability. We have therefore carried out a comprehensive study to determine the structural requirements for flavonoid potency and selectivity against platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. We conclude from this study that catechols are essential for high potency, that isoflavones and isoflavanones tend to select against 12-hLO, that isoflavans tend to select against 15-hLO-1, but few flavonoids target 15-hLO-2.