957344-74-0

Basic information

• Product Name: 5,8-DibroMoiMidazo[1,2-a]pyrazine
• Synonyms: 5,8-DibroMoiMidazo[1,2-a]pyrazine
• CAS NO: 957344-74-0
• Molecular Formula: C₆H₃Br₂N₃
• Molecular Weight: 276.91612
• Mol File: 957344-74-0.mol

Chemical Properties

• Appearance: /
• Density: 2.35±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.30±0.30(Predicted)
• CAS DataBase Reference: 5,8-DibroMoiMidazo[1,2-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-DibroMoiMidazo[1,2-a]pyrazine(957344-74-0)
• EPA Substance Registry System: 5,8-DibroMoiMidazo[1,2-a]pyrazine(957344-74-0)

Safety Data

• Hazardous Substances Data: 957344-74-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5,8-dibromoimidazo[1,2-a]pyrazine is used as a building block for the development of new drugs. Its unique chemical and physical properties contribute to the creation of innovative pharmaceutical products with potential therapeutic benefits.
Used in Agrochemical Industry:
5,8-dibromoimidazo[1,2-a]pyrazine is used as a building block for the development of new agrochemical products. Its unique properties can be harnessed to create novel compounds with potential applications in agriculture, such as pesticides or herbicides, to improve crop protection and yield.
Used in Medicinal Chemistry Research:
5,8-dibromoimidazo[1,2-a]pyrazine is used as a valuable compound in medicinal chemistry research. Its promising biological activities make it a potential candidate for the development of new synthetic pathways and drug discovery processes.
Used in Agricultural Chemistry Research:
5,8-dibromoimidazo[1,2-a]pyrazine is used as a valuable compound in agricultural chemistry research. Its unique properties can be explored to develop new agrochemical products, enhancing crop protection and contributing to sustainable agriculture practices.

Upstream product

• 957230-70-5 3,6-dibromopyrazin-2-amine 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 17157-48-1 bromoacetaldehyde 

Downstream Products

• 957344-77-3 (5-bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-chloro-phenyl)-amine 
• 1169391-98-3 4-(5-bromoimidazo[1,2-a]pyrazin-8-ylamino)-N-(2-diethylaminoethyl)benzenesulfonamide 
• 957344-95-5 (5-bromoimidazo[1,2-a]pyrazin-8-yl)-(4-(4-methylpiperazin-1-yl)phenyl)amine 
• 957345-26-5 (5-bromo-imidazo[1,2-a]pyrazin-8-yl)-[4-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-amine 
• 957346-50-8 (5-bromoimidazo[1,2-a]pyrazin-8-yl)-4-(4-morpholino-4-ylphenyl)amine 
• 1169393-38-7 4-(5-bromoimidazo[1,2-a]pyrazin-8-ylamino)-N-(4-hydroxybenzyl)benzamide 
• 957346-43-9 4-(5-bromoimidazo[1,2-a]pyrazin-8-ylamino)benzoic acid 
• 957345-90-3 (5-bromo-imidazo[1,2-a]pyrazin-8-yl)-[4-(4-isopropyl-piperazin-1-yl)-phenyl]-amine 
• 1169533-32-7 (5-bromo-imidazo[1,2-a]pyrazin-8-yl)-[4-(1-isopropylpiperidin-4-yl)-phenyl]amine 
• 957345-77-6 4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide 

Relevant articles and documents

FUSED PYRAZINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON TAK1

A compound selected from pyrazine fused-ring derivatives of a chemical formula 1 or pharmaceutically acceptable salts thereof has excellent inhibition activity with respect to TAK1 kinase. A pharmaceutical composition comprising the same is capable of increasing activity of anticancer drugs with respect to cancer or tumor by inhibiting activation of TAK1 kinase, with excellent effects as a prevention agent or a therapeutic agent of cancer or tumor. In the chemical formula 1, A, X, Y, W, Z, E, R^1, and m are the same as defined in the specification.COPYRIGHT KIPO 2016

Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis

MAPKAPK5 has been proposed to play a role in regulation of matrix metalloprotease expression and so to be a potential target for intervention in rheumatoid arthritis. We present here the identification of a series of compounds against this target which are effective in both biochemical and cell assays. The expansion of the series is described, along with early SAR and pharmacokinetics for some representative compounds.

FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel[1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula ( I ) represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.