957345-15-2Relevant academic research and scientific papers
A bile acid-based pyridino-triazole ligand for Cu(I)-stabilization and its application in Cu(I) catalyzed click reactions
Nayal, Aradhana,Pandey, Pramod S.
, (2020/10/23)
A bile acid based pyridino-triazole ligand to stabilize Cu(I) state has been developed. The ligand was found to catalyze click reactions of a number of alkynes and azides in presence of Cu(CH3CN)4.BF4 at very low catalyst
Arylation of Click Triazoles with Diaryliodonium Salts
Virant, Miha,Ko?mrlj, Janez
, p. 14030 - 14044 (2019/10/19)
A robust, selective, and highly efficient method for the preparation of 1,3,4-triaryl 1,2,3-triazolium salts has been developed. It features arylation of a click triazole with a diaryliodonium salt in the presence of a copper catalyst under neat condition
A comparison of novel organoiridium(III) complexes and their ligands as a potential treatment for prostate cancer
Hockey, Samantha C.,Barbante, Gregory J.,Francis, Paul S.,Altimari, Jarrad M.,Yoganantharajah, Prusothman,Gibert, Yann,Henderson, Luke C.
, p. 305 - 313 (2016/01/28)
A range of 1,4-substituted 2-pyridyl-N-phenyl triazoles were synthesised and evaluated for their antiproliferative properties against lymph node cancer of the prostate (LNCaP) and bone metastasis of prostate cancer (PC-3) cells. Excellent-to-low IC50 values were determined (5.6-250 μM), and a representative group of 4 ligands were then complexed to iridium(III) giving highly luminescent species. Reevaluation of these compounds against both cell lines was then undertaken and improved potency (up to 72-fold) was observed, giving IC50 values of 0.36-11 μM for LNCaP and 0.85-5.9 μM for PC-3. Preliminary screens for in vivo toxicity were conducted using a zebrafish model showing a wide range of induced toxicity depending of the compound evaluated. Apoptosis and Caspase-3 levels were also determined and showed no statistical difference between some of the treated specimens and the controls. This study may identify novel therapeutic agents for advanced stage of prostate cancer in humans.
Tricarbonylrhenium complexes from 2-pyridyl-1,2,3-triazole ligands bearing a 4-substituted phenyl arm: A combined experimental and theoretical study
Wolff, Mariusz,Munoz, Luc,Francois, Alison,Carrayon, Chantal,Seridi, Achour,Saffon, Nathalie,Picard, Claude,Machura, Barbara,Benoist, Eric
, p. 7019 - 7031 (2013/08/25)
Three new pyridyltriazole ligands (named pyta) bearing a 4-substituted phenyl arm (nitro- (2a), chloro- (2b) or aminophenyl (2c) moiety) have been synthesized using a convenient click chemistry strategy. The corresponding tricarbonylrhenium complexes 3a,
Rhenium(I) complexes of readily functionalized bidentate pyridyl-1,2,3-triazole "click" ligands: A systematic synthetic, spectroscopic and computational study
Kim, Tae Y.,Elliott, Anastasia B.S.,Shaffer, Karl J.,John McAdam,Gordon, Keith C.,Crowley, James D.
supporting information, p. 1391 - 1398 (2013/07/19)
A family of electronically tuned fac-Re(CO)3Cl pyridyl-1,2,3-triazole complexes have been synthesized by refluxing methanol solutions of [Re(CO)5Cl] and the substituted 2-(1-R-1H-1,2,3-triazol- 4-yl)pyridine ligands (pytri-R). The re
IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
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Page/Page column 71-72, (2008/06/13)
Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula ( I ) represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.
