957507-55-0

Basic information

• Product Name: 2-CYCLOHEXYLMETHYL-5-METHYL-2H-PYRAZOL-3-YLAMINE
• Synonyms: ASINEX-REAG BAS 06502062;2-CYCLOHEXYLMETHYL-5-METHYL-2H-PYRAZOL-3-YLAMINE
• CAS NO: 957507-55-0
• Molecular Formula: C11H19N3
• Molecular Weight: 193.29
• Mol File: 957507-55-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CYCLOHEXYLMETHYL-5-METHYL-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYCLOHEXYLMETHYL-5-METHYL-2H-PYRAZOL-3-YLAMINE(957507-55-0)
• EPA Substance Registry System: 2-CYCLOHEXYLMETHYL-5-METHYL-2H-PYRAZOL-3-YLAMINE(957507-55-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 957507-55-0(Hazardous Substances Data)

Upstream product

• 149267-56-1 N-1-(tert-butoxycarbonyl)-N-2-(cyclohexylmethyl)hydrazine 
• 2043-61-0 cyclohexanecarbaldehyde 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.