957540-36-2

Usage

Uses

Used in Pharmaceutical Research:
1-(3-Pyrrolidinyl)-pyrrolidine 2HCl is used as a building block for the synthesis of various molecules, contributing to the development of novel drugs.
Used in Therapeutic Applications:
1-(3-Pyrrolidinyl)-pyrrolidine 2HCl is used as a potential therapeutic agent for the treatment of neurological and psychiatric disorders, due to its unique structure and properties.
Used in Organic Synthesis:
1-(3-Pyrrolidinyl)-pyrrolidine 2HCl is used as a chiral auxiliary in organic synthesis, leveraging its stereochemical properties to enhance the synthesis process.
Used in Chemical Industry:
1-(3-Pyrrolidinyl)-pyrrolidine 2HCl is utilized in the chemical industry for its versatility and potential applications in various chemical processes and product development.

Upstream product

• 900164-96-7 (R)-1'-benzyl-[1,3']bipyrrolidinyl 
• 1215039-65-8 C₁₃H₂₄N₂O₂ 
• 913702-27-9 tert-butyl (R)-[1,3'-bipyrrolidine]-1'-carboxylate 
• 859213-31-3 (S)-1-benzyl-3-(1-pyrrolidinyl)pyrrolidine 

Relevant academic research and scientific papers

C-3 NOVEL TRITERPENONE WITH C-28 AMIDE DERIVATIVES AS HIV INHIBITORS

The invention relates to C-3 novel triterpenone with C-28 amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases (formula 1).

SUBSTITUTED 2, 4-DIAMINO-QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES

This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein which exhibit strong inhibition effects on various cancer cell lines. The compounds disclosed herein are useful for the treatment of proliferative diseases, including neoplastic diseases such as cancer and non- neoplastic disorders such as rheumatoid arthritis. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient and optionally one or more additional therapeutically active agents, including anticancer agents. This application also discloses methods for treating a proliferative disease, including neoplastic diseases such as cancer and non- neoplastic disorders such as rheumatoid arthritis.

Chiral 3-aminopyrrolidines as a rigid diamino scaffold for organocatalysis and organometallic chemistry

Over 20 new and easily prepared diamines were screened for the asymmetric Morita-Baylis-Hillman reaction. Chiral non-racemic 3-(N,N-dimethylamino)-1- methylpyrrolidine was found to promote efficiently the reaction of methyl vinyl ketone and substituted benzaldehydes. Enantiomeric excesses up to 73% were reached with electron-deficient benzaldehyde derivatives. After a simple deprotonation, one of these diamines was transformed into a chiral mixed aggregate for the enantioselective synthesis of (R)-1-o-tolylethanol with 76% ee.

N-benzoyl- and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.

AMIDE DERIVATIVE AND MEDICINE

The present invention is directed to an amide derivative having excellent BCR-ABL tyrosine kinase inhibitory activity, or a salt thereof. The present invention provides an amide derivative represented by the following general formula [1]: (wherein R1 represents -CH2-R11, etc.; R2 represents alkyl, halogen, haloalkyl, etc.; R3 represents hydrogen, etc.; Het1 represents a group of the formula [6] as above, etc.; and Het2 represents pyrimidinyl, etc.), or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.