95761-91-4

Usage

Uses

Used in Pharmaceutical Industry:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, [6R-(6α,7β)]is used as a prodrug for cefotiam in the pharmaceutical industry. It is administered as its dihydrochloride salt, which is then metabolized in the body to release the active antibiotic cefotiam. This prodrug approach allows for improved drug delivery and enhanced bioavailability of the antibiotic, making it more effective in treating bacterial infections.

InChI:InChI=1/C27H37N9O7S3/c1-15(42-27(40)43-18-7-5-4-6-8-18)41-24(39)21-16(13-46-26-31-32-33-35(26)10-9-34(2)3)12-44-23-20(22(38)36(21)23)30-19(37)11-17-14-45-25(28)29-17/h14-15,18,20,23H,4-13H2,1-3H3,(H2,28,29)(H,30,37)/t15?,20-,23-/m1/s1

Upstream product

• 99464-83-2 1-chloroethyl cyclohexyl carbonate 
• 95789-69-8 cyclohexyl (1-iodoethyl)carbonate 

Relevant academic research and scientific papers

Method for preparing cefotiam hexetil hydrochloride

The invention discloses a method for preparing cefotiam hexetil hydrochloride. The method comprises the following steps: preparing cefotiam hexetil free alkali through choride iodination and one-pot esterification method by taking stable raw materials such as cefotiam hexetil hydrochloride and chlorinated carbonate as initial materials; performing low-temperature concentration, devitrification and other processes, thereby obtaining the purified cefotiam hydrochloride free alkali; and finally, carrying out a hydrochloride formation reaction, thereby obtaining the cefotiam hexetil hydrochloride. The method has the characteristics of high reaction stability and controllability, low product impurity content, simplicity in industrialized production and the like.

Preparation method of high-purity cefotiam hexetil dihydrochloride

The invention discloses a preparation method of cefotiam hexetil dihydrochloride. The method comprises the steps that cefotiam hydrochloride is used as a raw material for synthesizing cefotiam alkali metal salt; the cefotiam alkali metal salt and 1-iodoet