958-79-2

Basic information

• Product Name: 1,3-dibromo-1,3-diphenylpropan-2-one
• Synonyms: 1,3-Dibromo-1,3-diphenyl-2-propanone; 2-Propanone, 1,3-dibromo-1,3-diphenyl-
• CAS NO: 958-79-2
• Molecular Formula: C₁₅H₁₂Br₂O
• Molecular Weight: 368.0632
• Mol File: 958-79-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 399.5°C at 760 mmHg
• Flash Point: 97.7°C
• Density: 1.639g/cm³
• Vapor Pressure: 1.37E-06mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 1,3-dibromo-1,3-diphenylpropan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dibromo-1,3-diphenylpropan-2-one(958-79-2)
• EPA Substance Registry System: 1,3-dibromo-1,3-diphenylpropan-2-one(958-79-2)

Safety Data

• Hazardous Substances Data: 958-79-2(Hazardous Substances Data)

Usage

General Description

1,3-dibromo-1,3-diphenylpropan-2-one is a chemical compound that contains two bromine atoms and a phenylpropan-2-one backbone. It is a yellow solid with a distinct odor and is primarily used as a reagent in chemical reactions and synthesis. It is a highly reactive compound and is often used as a building block in the production of various pharmaceuticals and agrochemicals. Its main applications include its use as a precursor in the synthesis of organic compounds and as a reagent in the preparation of complex molecules. Additionally, it is also used in research laboratories for various organic chemistry experiments and reactions.

Upstream product

• 102-04-5 1,3-Diphenylpropanone 

Downstream Products

• 55816-76-7 1-(5,6-dimethyl-7ξ-oxo-3,7ξ-diphenyl-2-thia-7λ⁵-phospha-bicyclo[2.2.1]hept-5-en-3exo-yl)-2-phenyl-ethanone 
• 55816-77-8 8ξ-oxo-1,2endo,4endo,5,8ξ-pentaphenyl-8λ⁵-phospha-bicyclo[3.2.1]oct-6-en-3-one 
• 91817-56-0 C₂₅H₂₄O 
• 91877-84-8 C₂₅H₂₄O 
• 97806-22-9 C₂₅H₂₄O 
• 103077-53-8 8,8-Dimethoxy-2,4-diphenylbicyclo<3.2.1>oct-6-en-3-on 
• 97486-54-9 1,3,3a,4,4a,5,6,7,7a,7b-decahydro-2-keto-3a-methyl-4-<(4methylphenyl)sulfonyl>-1,3-diphenyldicyclopenta-pyrrole 
• 97486-45-8 4-carbomethoxy-2,6-diphenylcyclohexanone 

Relevant articles and documents

Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone

An unprecedented C═C double bond cleavage of cyclopropenone and dioxygen activation by multiyne cascade coupling has been developed. This chemistry provides a novel, simple, and efficient approach to synthesize fully substituted conjugate benzofuran derivatives from simple substrates under mild conditions. The density functional theory (DFT) calculations reveal that the unique homolytic cleavages of cyclopropenone and molecular oxygen are crucial to the success of this reaction.

Organocatalytic Regiodivergent C?C Bond Cleavage of Cyclopropenones: A Highly Efficient Cascade Approach to Enantiopure Heterocyclic Frameworks

Here a highly efficient cascade approach is reported that combines a cycloaddition reaction with a regioselective strain-release process to afford diverse heterocyclic frameworks through bifunctional catalysis. The cooperation of hydrogen-bonding network activation and a regiodivergent strain-assisted effect is the key to promoting this complex chemical transformation, leading to the generation of two different ring systems in high yields with excellent stereoselectivities. The reaction proceeded by a mechanism involving a “spring-loaded” intermediate with switchable C?C bond cleavages achieved by controllable ring-strain release. This reaction was also amenable to gram scale synthesis with only 0.1 mol % catalyst loading.

Cyclopropenone catalyzed substitution of alcohols with mesylate ion

The cyclopropenone catalyzed nucleophilic substitution of alcohols by methanesulfonate ion with inversion of configuration is described. This work provides an alternative to the Mitsunobu reaction that avoids the use of azodicarboxylates and generation of hydrazine and phosphine oxide byproducts. This transformation is shown to be compatible with a range of functionality. A cyclopropenone scavenge strategy is demonstrated to aid purification.