95813-31-3Relevant academic research and scientific papers
Decarboxylative aromatization of β-carbolines by using metal free catalysis and efficient synthesis of β-carboline derivatives
Rao, Chunduru Srinivasa,Reddy, Ch. Venkata Ramana,Devi, B. Rama,Vantikommu, Jyothi,Cherukuri, Jyotna,Sait, Shakil S.
, p. 4701 - 4702 (2015)
A new novel metal-free decarboxylative and aromatized β-carboline (5a-j) derivatives were synthesized by one-pot reaction. In all cases, resulting β-carboline derivatives with above 90 % yield.
Organic base-promoted efficient dehydrogenative/decarboxylative aromatization of tetrahydro-β-carbolines into β-carbolines under air
Zhao, Ziquan,Sun, Yan,Wang, Lilin,Chen, Xuan,Sun, Yanpei,Lin, Long,Tang, Yulin,Li, Fei,Chen, Dongyin
supporting information, p. 800 - 804 (2019/02/16)
Organic base DBN has been identified as an efficient reagent for promoting the dehydrogenative/decarboxylative aromatization of tetrahydro-β-carbolines under air atmosphere, to access the corresponding β-carbolines in moderate to good yields. The utility of this protocol for the gram-scale synthesis of β-carboline alkaloids eudistomin U (7) and harmane (10) has also been demonstrated.
Total syntheses of eudistomins Y1-Y7 by an efficient one-pot process of tandem benzylic oxidation and aromatization of 1-benzyl-3,4-dihydro-β-carbolines
Trieu, Tien Ha,Dong, Jing,Zhang, Qiang,Zheng, Bo,Meng, Tian-Zhuo,Lu, Xia,Shi, Xiao-Xin
supporting information, p. 3271 - 3277 (2013/07/05)
The first total synthesis of eudistomin Y7 (7) and total syntheses of eudistomins Y1-Y6 (1-6) are described. An efficient room-temperature conversion of 1-benzyl-3,4-dihydro-β-carbolines (11) into 1-benzoyl-β-carbolines (14) by a one-pot process of tandem benzylic oxidation and aromatization as the key step of these total syntheses was also studied in detail. The first total synthesis of eudistomin Y 7 (7) and total syntheses of eudistomins Y1-Y6 (1-6) are described. An efficient room-temperature conversion of 1-benzyl-3,4-dihydro-β-carbolines (11) into 1-benzoyl-β-carbolines (14) by a one-pot process of tandem benzylic oxidation and aromatization as the key step of these total syntheses was also studied in detail. Copyright
β-Carbolines as specific inhibitors of cyclin-dependent kinases
Song, Yongcheng,Wang, Jian,Teng, Su Fern,Kesuma, Djohan,Deng, Yu,Duan, Jinao,Wang, Jerry H.,Qi, Robert Zhong,Sim, Mui Mui
, p. 1129 - 1132 (2007/10/03)
Harmine (3), 7-fluoro-1-methyl β-carboline (35) and 1-(5-methyl-imidazol-4-yl) β-carboline (41) were potent and specific inhibitors of cyclin-dependent kinases. The degree of aromaticity of the tricyclic ring and the positioning of substituents are important for inhibitory activity. While most β-carbolines inhibited CDK2 and CDK5 to the same extent, selective inhibition against CDK2 was observed in 1-(2-chlorophenyl)- (12), 1-(2-fluorophenyl)- (15), and 1-(2-chloro-5-nitrophenyl)- (28) β-carbolines.
