958236-52-7Relevant academic research and scientific papers
β-type glycosidic bond formation by palladium-catalyzed decarboxylative allylation
Xiang, Shaohua,Lu, Zhiqiang,He, Jingxi,Hoang, Kim Le Mai,Zeng, Jing,Liu, Xue-Wei
supporting information, p. 14047 - 14051 (2013/11/19)
The efficient and stereoselective construction of glycosidic linkages is of great significance in carbohydrate chemistry due to the ubiquitous existence of numerous biologically active natural products and saccharides. Although great efforts have been devoted to stereoselective glycosylations in the past few decades, constructing glycosidic bonds with high efficiency and selectivity remains a challenge and continues to be an important area in carbohydrate research. Phenols are widely used as nucleophiles in palladium-catalyzed allylation. In contrast, the possibility of using aliphatic alcohols as nucleophiles is not as thoroughly explored. The modified reaction conditions were then applied to other substrates. Originating from easily prepared carbonates, various glycosides, such as phenolic Oglycosides, thiophenolic S-glycoside, aliphatic O-glycosides, and even disaccharides, were synthesized in good yields by means of a palladium-catalyzed decarboxylative allylation.
