958301-30-9Relevant academic research and scientific papers
Convenient synthesis of 3-substituted benzo[b]thiophenes by iodine-mediated cyclization of α-substituted 2-(1-Phenylethylthio)styrenes
Kobayashi, Kazuhiro,Nakamura, Daizo,Miyamoto, Kazuna,Morikawa, Osamu,Konishi, Hisatoshi
, p. 1780 - 1784 (2007)
A new and convenient method for the preparation of 3-substituted benzo[b]thiophenes was developed. α-Substituted 2-(1-phenylethylthio) styrenes, which could easily be prepared from 2-mercaptophenyl ketones or benzenethiols in two or three steps, respectively, underwent 5-endo cyclization on treatment with iodine in the presence of sodium hydrogencarbonate in acetonitrile at room temperature to give 3-substituted benzo[b]thiophenes in fair to good yields.
