958332-47-3

Basic information

• Product Name: methyl 6-isopropenyl-2-naphthoate
• CAS NO: 958332-47-3
• Molecular Weight: 226.275
• Mol File: 958332-47-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 6-isopropenyl-2-naphthoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-isopropenyl-2-naphthoate(958332-47-3)
• EPA Substance Registry System: methyl 6-isopropenyl-2-naphthoate(958332-47-3)

Safety Data

• Hazardous Substances Data: 958332-47-3(Hazardous Substances Data)

Upstream product

• 101513-13-7 methyl 6-isopropyl-2-naphthoate 

Downstream Products

• 958329-37-8 (R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE 

Relevant articles and documents

Synthesis of 6-hydroxy-2-naphthoic acid from 2,6-diisopropylnaphthalene using NHPI as a key catalyst

A new strategy to 6-hydroxy-2-naphthoic acid (HNPA) and 4-hydroxybenzoic acid from 2,6-diisopropylnaphthalene and p-cymene, respectively, was developed using the NHPI-catalyzed aerobic oxidation as a principal reaction. 2,6-Diisopropylnaphthalene was oxidized by the oxidation with O2 (1 atm) by NHPI (10 mol %) combined with Co(OAc)2 (0.5 mol %) to give 6-acetyl-2-isopropylnaphthalene, which then was converted to 6-isopropyl-2-naphthoic acid under O2 (1 atm) in the presence of Co(OAc)2 (0.5 mol %) and Mn(OAc)2 (0.5 mol %). Esterification of the resulting acid followed by the aerobic oxidation produced methyl 6-hydroxy-2-naphthoate whose hydrolysis led to the desired HNPA. An alternative route involves the oxidation of 6-acetyl-2-isopropylnaphthalene to 6-acetyl-2-naphthol on which subsequent oxidation and deacetylation gave HNPA. This method was successfully extended to the synthesis of 4-hydroxybenzoic acid from p-cymene.