95835-64-6Relevant academic research and scientific papers
Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines
Huang, Yuhua,Bennett, Frank,Girijavallabhan, Vinay,Alvarez, Carmen,Chan, Tze-Ming,Osterman, Rebecca,Senior, Mary,Kwong, Cecil,Bansal, Namita,George Njoroge,MacCoss, Malcolm
scheme or table, p. 2800 - 2802 (2010/07/04)
A general synthetic approach to 4,6-substituted thiazole[4,5-c]pyridines, involving a novel one-pot thiol deprotection-cyclization key step, is described.
Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagonists
Dzierba, Carolyn D.,Takvorian, Amy G.,Rafalski, Maria,Kasireddy-Polam, Padmaja,Wong, Harvey,Molski, Thaddeus F.,Zhang, Ge,Li, Yu-Wen,Lelas, Snjezana,Peng, Yong,McElroy, John F.,Zaczek, Robert C.,Taub, Rebecca A.,Combs, Andrew P.,Gilligan, Paul J.,Trainor, George L.
, p. 5783 - 5790 (2007/10/03)
Corticotropin releasing factor (CRF) is the primary regulator of the hypothalamus-pituitary-adrenal (HPA) axis, coordinating the endocrine, behavioral, and autonomic responses to stress. It has been postulated that small molecules that can antagonize the
Certain alkylene diamine-substituted heterocycles
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, (2008/06/13)
The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPY1receptor. The present invention provides novel, potent, non-peptidic antagonists of NP
Arylamino fused pyrimidines
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, (2008/06/13)
Corticotropin releasing factor (CRF) antagonists of formula I or formula II: and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
1N-alkyl-N-arylpyrimidinamines and derivatives thereof
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, (2008/06/13)
The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R1, R3, R4, R5, Z, Y, V, X, X', J, K, L, and M are as defined herein.
Thrombin inhibitors
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, (2008/06/13)
A compound which inhibits human thrombin and where has the structure
