95838-64-5

Basic information

• Product Name: 1H-Pyrrole-3-carboxylic acid, 2,5-dimethyl-4-(4-nitrophenyl)-, ethyl ester
• CAS NO: 95838-64-5
• Molecular Formula: C15H16N2O4
• Molecular Weight: 288.303
• Mol File: 95838-64-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxylic acid, 2,5-dimethyl-4-(4-nitrophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxylic acid, 2,5-dimethyl-4-(4-nitrophenyl)-, ethyl ester(95838-64-5)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxylic acid, 2,5-dimethyl-4-(4-nitrophenyl)-, ethyl ester(95838-64-5)

Safety Data

• Hazardous Substances Data: 95838-64-5(Hazardous Substances Data)

Upstream product

• 4231-16-7 1-(p-nitrophenyl)-2-nitro-1-propene 
• 141-97-9 ethyl acetoacetate 
• 5303-65-1 3-aminobutanoic acid ethyl ester 
• 6159-25-7 1-<(4-nitro)-phenyl>-1,2-propandione 
• 555-16-8 4-nitrobenzaldehdye 
• 95838-79-2 C₂₁H₂₄N₂O₈ 
• 52287-53-3 1-nitro-4-[(1E)-2-nitro-1-propenyl]benzene 
• 95863-85-7 2-Acetyl-4-aci-nitro-3-(4-nitrophenyl)pentansaeure-ethylester 

Downstream Products

• 562072-26-8 1-benzyl-2,5-dimethyl-4-(4-nitrophenyl)-1H-pyrrole-3-carboxylic acid 

Relevant articles and documents

Transaminase-Mediated Amine Borrowing via Shuttle Biocatalysis

Shuttle catalysis has emerged as a useful methodology for the reversible transfer of small functional groups, such as CO and HCN, and goes far beyond transfer hydrogenation chemistry. While a biocatalytic hydrogen-borrowing methodology is well established, the biocatalytic borrowing of alternative functional groups has not yet been realized. Herein, we present a new concept of amine borrowing via biocatalytic shuttle catalysis, which has no counterpart in chemo-shuttle catalysis and allows efficient intermolecular amine shuttling to generate reactive intermediates in situ. By coupling this dynamic exchange with an irreversible downstream step to displace the reaction equilibrium in the forward direction, high conversion to target products can be achieved. We showcase the potential of this amine-borrowing methodology using a biocatalytic equivalent of both the Knorr-pyrrole synthesis and Pictet-Spengler reaction.

ANDROGEN RECEPTOR ANTAGONISTS

The present invention provides an androgen receptor antagonistic agent and a superior prophylactic or therapeutic agent for hormone-sensitive cancer, which contain a compound of the formula: wherein, R1 is a hydrogen atom, a group binding through a carbon atom, a group binding through a nitrogen atom, a group binding through an oxygen atom or a group binding through a sulfur atom; R2 is a hydrogen atom, a group binding through a carbon atom, a group binding through a nitrogen atom, a group binding through an oxygen atom or a group binding through a sulfur atom, R3 is a hydrogen atom, a hydrocarbon group which may have substituent (s) , an acyl group or a heterocyclic group which may have substituent(s), R4 is a hydrogen atom, a group binding through a carbon atom, a group binding through a nitrogen atom, a group binding through an oxygen atom or a group binding through a sulfur atom, and R5 is a cyclic group which may have substituent(s); or a salt thereof, or its prodrug.