958394-46-2Relevant academic research and scientific papers
Benzofuran-derived cyclic β-amino acid scaffold for building a diverse set of flavonoid-like probes and the discovery of a cell motility inhibitor
Nandy, Jyoti P.,Rakic, Bojana,Sarma, Bugga V.N.B.,Babu, Nallareddy,Lefrance, Marc,Enright, Gary D.,Leek, Donald M.,Daniel, Kate,Sabourin, Luc A.,Arya, Prabhat
supporting information; experimental part, p. 1143 - 1146 (2009/04/06)
We report here a practical, Enantioselective synthesis of benzofuran-deriwed, cyclic trans-β-amino acid scaffold. In two cases, tricyclic derivatives having six- and eight-membered unsaturated lactams were obtained from this versatile scaffold. To explore the biological applications, these compounds were subjected to cell-based assays, using NIH3T3 mouse cells to examine their potency as cell motility inhibitors and identified 18 as a potent cell motility inhibitor (IC5040 μM in chamber cell migration assay).
