958445-35-7Relevant academic research and scientific papers
N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-d iamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease
Huang, Wenwei,Zheng, Wei,Urban, Daniel J.,Inglese, James,Sidransky, Ellen,Austin, Christopher P.,Thomas, Craig J.
, p. 5783 - 5789 (2008/02/13)
A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.
