95848-59-2

Basic information

• Product Name: α-oxo-N-phenyl-α-(4-fluorophenyl)ethanehydrazonoyl bromide
• CAS NO: 95848-59-2
• Molecular Weight: 321.149
• Mol File: 95848-59-2.mol

Chemical Properties

• CAS DataBase Reference: α-oxo-N-phenyl-α-(4-fluorophenyl)ethanehydrazonoyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: α-oxo-N-phenyl-α-(4-fluorophenyl)ethanehydrazonoyl bromide(95848-59-2)
• EPA Substance Registry System: α-oxo-N-phenyl-α-(4-fluorophenyl)ethanehydrazonoyl bromide(95848-59-2)

Safety Data

• Hazardous Substances Data: 95848-59-2(Hazardous Substances Data)

Upstream product

• 95848-51-4 1-(4-Fluoro-phenyl)-2-(phenyl-hydrazono)-ethanone 

Downstream Products

• 107378-03-0 1-[3-(4-Fluoro-benzoyl)-5-(4-fluoro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-ethanone 
• 97052-83-0 3-(4-Ethoxy-phenyl)-4-(4-fluoro-phenyl)-5-phenylazo-3H-thiazol-2-ylideneamine 
• 97053-34-4 2-(4-fluorophenyl)-6-(2-fluoro-5-methylphenyl)-3-phenylazo-1H-pyrazolo<5,1-a>imidazole 
• 107377-97-9 <4,5-Dihydro-5-iminochloroacetyl-4-phenyl-1,3,4-thiadiazol-2-yl-(4-fluoro)>phenylmethanone 
• 107377-94-6 N-[5-(4-Fluoro-benzoyl)-3-phenyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-acetamide 
• 97052-89-6 2,6-bis(4-fluorophenyl)-1-morpholinomethyl-3-phenylazopyrazolo<5,1-a>imidazole 
• 97052-88-5 1-acetyl-2,6-bis(4-fluorophenyl)-3-phenylazopyrazolo<5,1-a>imidazole 
• 97053-31-1 [2-(4-Fluoro-phenyl)-6-phenyl-5H-imidazo[1,2-b]pyrazol-3-yl]-phenyl-diazene 
• 107378-01-8 1-[3-(4-Fluoro-benzoyl)-5-methyl-1-phenyl-1H-pyrazol-4-yl]-ethanone 
• 97064-85-2 2,6-bis(4-fluorophenyl)-3-phenylazo-1H-pyrazolo<5,1-a>imidazole 
• 107377-98-0 4-(4-Fluoro-phenyl)-5-phenylazo-thiazol-2-ylamine 
• 107377-86-6 <4,5-Dihydro-5-imino-4-phenyl-1,3,4-thiadiazol-2-yl-(4-fluorophenyl)>methanone 
• 97052-75-0 2-(4-fluorophenyl)-3-phenylazoimidazo<1,2-a>pyridine 

Relevant articles and documents

Facile Synthesis of Fluorine-containig methanone, 2-Amino-4-aryl-5-arylazothiazoles and 3-Aroyl-4-acetyl/benzoyl-5-methyl-1-phenylpyrazoles through N-Aryl-α-oxo-α-arylethanehydrazonoyl Bromide

N-Aryl-α-oxo-α-arylethanehydrazonoyl bromides 2 react with potassium thiocyanate in ethanol leading to the formation of methanone 5 in quantitative yield.Treatment of 2 with thiourea and β-diketones affords 2-amino-4-aryl-5-arylazothiazoles 4 and 3-aroyl-4-acetyl/benzoyl-5-methyl-1-phenylpyrazoles 6 in 65-70 and 60-70percent yields respectively.Compound 5 has also been subjected to acylation and chloroacetylation.All the compounds are characterized by their analytical and spectral (ir, 1H-nmr and ms) data.Mass fragmentation patterns of these compounds are discussed.

FACILE SYNTHESIS OF FLUORINE CONTAINING IMIDAZO TRIAZINES THROUGH α-OXO-N-ARYL-α ARYLETHANEHYDRAZONOYL BROMIDES

Treatment of fluorine containing arylglyoxals with aminoguanidine bicarbonate in aqueous ethanol formed fluorinated 3-amino-5-aryltriazines which in turn on treatment with α-oxo-N-aryl-α-arylethanehydrazonoyl bromides afforded 3,6-diaryl-7-arylazoimidazo triazines in 75-80percent yield.All the compounds were characterized by their analytical and spectral (IR, PMR and Mass) data.Mass fragmentation patterns of these compounds have also been discussed.The screening of biological activities are in progress.

Facile Synthesis of Fluorine Containing Imidazopyridines, Pyrazoloimidazoles and 2-Iminoarylazothiazoles through &α-Oxo-N-aryl-&α-arylethanehydrazonoyl Bromides

α-Oxo-N-aryl-α-arylethanehydrazonoyl bromides (I) react with 5-amino-3-arylpyrazole in ethanol to form 2,6-diaryl-3-arylazo-1H-pyrazoloimidazoles (II) in quantitative yields.Treatment of I with 2-aminopyridine and 1-p-ethoyphenyl-2-thiourea affords 2-aryl-3-arylazoimidazopyridines (III) and 4-aryl-5-arylazo-2-iminothiazoles (IV) in 70 - 80 and 60 - 70percent yields, respectively.Compound IIb (X=Z=4-F; R=Y=H) has been subjected to acetylation and Mannich reaction.All the compounds have been characterized by their analytical and spectral (IR, PMR and mass) data.Representative compounds have been screened for their antiimplantation activity in adult female rats at 20 mg/kg dose.