958594-92-8

Basic information

• Product Name: C₂₀H₁₉N₃O₅S
• CAS NO: 958594-92-8
• Molecular Weight: 413.454
• Mol File: 958594-92-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₉N₃O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₉N₃O₅S(958594-92-8)
• EPA Substance Registry System: C₂₀H₁₉N₃O₅S(958594-92-8)

Safety Data

• Hazardous Substances Data: 958594-92-8(Hazardous Substances Data)

Upstream product

• 958582-27-9 C₂₀H₁₇N₃O₇S 

Relevant articles and documents

Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: Heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay

Heat shock protein 90 is emerging as an important target in cancer chemotherapy. In a program directed toward identifying novel chemical probes for Hsp90, we found N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)benzene sulfonamide as an Hsp90 inhibitor with very weak activity. In this report, we present a new and general method for the synthesis of a variety of analogs around this scaffold, and discuss their structure-activity relationships.