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Usage

Uses

Used in Cosmetics and Pharmaceuticals:
(E)-1-(4-Hydroxyphenyl)dec-1-en-3-one is used as an active ingredient in the cosmetics and pharmaceutical industries for its antioxidant and anti-inflammatory properties. These characteristics make it suitable for products aimed at promoting skin health and reducing inflammation.
Used in Flavor and Fragrance Production:
In the flavor and fragrance industry, (E)-1-(4-Hydroxyphenyl)dec-1-en-3-one is used as a key component for its pleasant aroma. Its unique scent makes it a valuable addition to the creation of various fragrances and flavorings.
Used in Cancer Prevention and Treatment Research:
(E)-1-(4-Hydroxyphenyl)dec-1-en-3-one is also being studied for its potential role in cancer prevention and treatment. Its anti-cancer properties suggest that it could be a valuable compound in the development of new therapeutic strategies against various types of cancer.
Overall, (E)-1-(4-Hydroxyphenyl)dec-1-en-3-one is a versatile compound with a wide range of potential applications in the cosmetics, pharmaceuticals, flavor and fragrance, and medical research industries. Its unique properties make it a promising candidate for further development and utilization in these fields.

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Relevant academic research and scientific papers

Gibbilimbol analogues as antiparasitic agents - Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum

The essential oils from leaves of Piper malacophyllum (Piperaceae) showed to be mainly composed by two alkenylphenol derivatives: gibbilimbols A and B. After isolation and structural characterization by NMR and MS data analysis, both compounds were evaluated against promastigote/amastigote forms of Leishmania (L.) infantum as well as trypomastigote/amastigote forms of Trypanosoma cruzi. The obtained results indicated that gibbilimbol B displayed potential against the tested parasites and low toxicity to mammalian cells, stimulating the preparation of several quite simple synthetic analogues in order to improve its activity and to explore the preliminary structure-activity relationships (SAR) data. Among the prepared derivatives, compound LINS03003 (n-octyl-4-hydroxybenzylamine) displayed the most potent IC50 values of 5.5 and 1.8 μM against amastigotes of T. cruzi and L. (L.) infantum, respectively, indicating higher activity than the natural prototype. In addition, this compound showed remarkable selectivity index (SI) towards the intracellular forms of Leishmania (SI = 13.1) and T. cruzi (SI = 4.3). Therefore, this work indicated that preparation of synthetic compounds structurally based in the bioactive natural products could be an interesting source of novel and selective compounds against these protozoan parasites.