958635-23-9Relevant academic research and scientific papers
Non-natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors
Florence, Gordon J.,Fraser, Andrew L.,Gould, Eoin R.,King, Elizabeth F. B.,Menzies, Stefanie K.,Morris, Joanne C.,Tulloch, Lindsay B.,Smith, Terry K.
supporting information, p. 2548 - 2556 (2015/04/22)
Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrahydropyran 1,4-triazole analogues based on the framework of chamuvarinin, a polyketide natural product isolated from the annonaceae plant species are deta
Non-natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors
Florence, Gordon J.,Fraser, Andrew L.,Gould, Eoin R.,King, Elizabeth F. B.,Menzies, Stefanie K.,Morris, Joanne C.,Tulloch, Lindsay B.,Smith, Terry K.
supporting information, p. 2548 - 2556 (2015/08/24)
Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrahydropyran 1,4-triazole analogues based on the framework of chamuvarinin, a polyketide natural product isolated from the annonaceae plant species are deta
Total synthesis and revision of the absolute configuration of seimatopolide B
Reddy, Chada Raji,Dilipkumar, Uredi,Reddy, Motatipally Damoder,Rao, Nagavaram Narsimha
, p. 3355 - 3364 (2013/06/05)
The asymmetric total synthesis of natural seimatopolide B along with its enantiomer is described starting from readily available 5-hexen-1-ol and 3-buten-1-ol. The key steps involved are Jacobson hydrolytic kinetic resolution, proline-catalyzed α-hydroxyl
"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides
Dey, Sangeeta,Powell, Douglas R.,Hu, Chunhua,Berkowitz, David B.
, p. 7010 - 7014 (2008/09/17)
(Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.
