958635-26-2

Upstream product

• 103791-54-4 (+/-)-6-[(tert-butyldiphenylsilyl)oxy]-1,2-epoxyhexane 

Downstream Products

• 1434059-29-6 (R)-tert-butyl(5-(4-methoxybenzyloxy)hept-6-enyloxy)diphenylsilane 
• 1434059-30-9 (R)-5-(4-methoxybenzyloxy)hept-6-en-1-ol 
• 1434059-31-0 (R)-5-(4-methoxybenzyloxy)hept-6-enal 
• 1206732-10-6 (2S,5R)-5-[(4-methoxybenzyl)oxy]hept-6-ene-1,2-diol 
• 1434059-32-1 (S)-2-((R)-3-(4-methoxybenzyloxy)pent-4-enyl)oxirane 
• 1434059-33-2 (3R,6R)-3-(4-methoxybenzyloxy)pentadec-1-en-6-ol 
• 1434059-34-3 (S)-((3R,6R)-3-(4-methoxybenzyloxy)pentadec-1-en-6-yl) 3-(tertbutyldimethylsilyloxy)pent-4-enoate 
• 1434059-35-4 (S)-((3R,6R)-3-(4-methoxybenzyloxy)pentadec-1-en-6-yl) 3-hydroxypent-4-enoate 
• 958635-16-0 (R)-6-[(tert-butyldiphenylsilyl)oxy]-1,2-epoxyhexane 
• 1434059-28-5 (R)-7-(tert-butyldiphenylsilyloxy)hept-1-en-3-ol 

Relevant academic research and scientific papers

Total synthesis and revision of the absolute configuration of seimatopolide B

The asymmetric total synthesis of natural seimatopolide B along with its enantiomer is described starting from readily available 5-hexen-1-ol and 3-buten-1-ol. The key steps involved are Jacobson hydrolytic kinetic resolution, proline-catalyzed α-hydroxyl

"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides

(Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.