958737-50-3Relevant academic research and scientific papers
An RCM strategy to stereodiverse δ-sultam scaffolds
Jimenez-Hopkins, Maria,Hanson, Paul R.
supporting information; experimental part, p. 2223 - 2226 (2009/05/11)
(Chemicall Equation Presented) An asymmetric approach for the synthesis of substituted δ-sultams with multiple synthetic handles is described. This study demonstrates the facile construction of a stereochemically diverse array of substituted δ-sultams, more specifically substituted 3,4,5,6-dihydro 1,2-thiazine 1,1-dioxides. A pivotal Mitsunobu alkylation/RCM sequence is used to assemble key allyl sultam building blocks possessing a C3 stereogenic handle. All subsequent reactions are achieved with high levels of diastereoselectivity to afford enantiopure δ-sultams in good yields.
