958751-28-5

Upstream product

• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 267901-75-7 6-bromo-5,7-dimethyl-4-phenyl-2H-chromen-2-one 
• 267901-42-8 4-bromo-3,-5-dimethyl-phenyl 3-phenylpropiolate 
• 7463-51-6 4-bromo-3,5-dimethylphenol 
• 637-44-5 phenylpropyolic acid 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32

In an effort to develop new and potent agents for therapy against tuberculosis, a high-throughput screen was performed against Mycobacterium tuberculosis strain H37Rv. Two 6-aryl-5,7-dimethyl-4-phenylcoumarin compounds 1a and 1b were found with modest activity. A series of coumarin derivatives were synthesized to improve potency and to investigate the structure-activity relationship of the series. Among them, compounds 1o and 2d showed improved activity with IC90 of 2 μM and 0.5 μM, respectively. Further optimization provided compound 3b with better physiochemical properties with IC90 0.4 μM which had activity in a mouse model of infection. The role of the conformation of the 4- and 6-aryl substituents is also described.