958752-68-6

Upstream product

• 267666-08-0 1-(benzylsulfonyl)piperidin-4-one 
• 149-73-5 trimethyl orthoformate 
• 41979-39-9 4-piperidone hydrochloride 
• 1939-99-7 benzenesulfonyl chloride 

Downstream Products

• 267666-43-3 trifluoromethanesulfonic acid 5-benzenesulfonyl-7-methoxy-2-phenylmethanesulfonyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester 
• 267666-27-3 5-benzenesulfonyl-8-hydroxy-7-methoxy-2-phenylmethanesulfonyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-37-5 5-benzenesulfonyl-7,8-dimethoxy-2-phenylmethanesulfonyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-14-8 4-methoxy-1-phenylmethanesulfonyl-1,2,3,6-tetrahydro-pyridine 

Relevant academic research and scientific papers

Lewis Acid-Directed Cyclocondensation of Piperidone Enol Ethers with 2-Methoxy-4-(N-phenylsulfonyl)-1,4-benzoquinoneimine: A New Regioselective Synthesis of Oxygenated Carbolines

Lewis acid-directed cyclocondensations of piperidone enol ethers with 2-methoxy-4-(N-phenylsulfonyl)-1,4-henzoquinoneimine are reported. Benzofurans are obtained with BF3·OEt2 as a promoter, whereas use of excess amounts of TiCl4:Ti(OiPr)4 leads to tetrahydrocarbolines. The latter reactions provide expedient routes to oxygen-substituted tetrahydrocarbolines and carbolines. As applications of this new methodology, the preparations of 1-[3-(dimethylamino)propyl]amino-7-methoxy- and 1-[3-(dimethylamino)propyl]amino-7,8-dimethoxy-5H-pyrido[4,3-b]indoles are described.