958752-88-0Relevant academic research and scientific papers
Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis
Tao, Ye,Gilbertson, Scott R.
, p. 11292 - 11295 (2018)
The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99?:?1 d.r.).
Domino heck-aza-Michael reactions: A one-pot, sequential three-component approach to 1,1-dioxido-1,2-benzisothiazoline-3-acetic acid
Rolfe, Alan,Young, Kyle,Hanson, Paul R.
experimental part, p. 5254 - 5262 (2009/06/06)
The development of a new method for the synthesis of 1,1-dioxido-1,2- benzisothiazoline-3-acetic acid by a domino process is reported whereby a classical Heck reaction is coupled to an intramolecular aza-Michael reaction. Ultimately, this method has been expanded to a one-pot, sequential three-component protocol to generate diverse benzofused γ-sultams from a range of commercially available α-bromobenzenesulfonyl chlorides, amines and Michael acceptors. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
