958872-99-6Relevant academic research and scientific papers
Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides
Lory, Pedro M.J.,Estrella-Jimenez, Maria E.,Shashack, Matthew J.,Lokesh, Ganesh L.,Natarajan, Amarnath,Gilbertson, Scott R.
, p. 5940 - 5943 (2008/09/21)
This manuscript describes methods appropriate for the parallel synthesis of libraries based on the tricyclic thioxanthen-9-one-10,10-dioxide scaffold. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and commercially available 3-carboxylic acid thioxanthen-9-one-10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alkaline phosphatase reported replicon system for activity against hepatitis C virus.
