959-81-9Relevant articles and documents
Rational Design of Crystallization-Induced-Emission Probes To Detect Amorphous Protein Aggregation in Live Cells
Bai, Yulong,Dong, Xuepeng,Gao, Zhenming,Huang, Yanan,Jin, Wenhan,Liu, Xiaojing,Liu, Yu,Lyu, Haochen,Piao, Hai-Long,Shen, Di,Tang, Yuqi,Wan, Wang,Wang, Mengdie,Zeng, Lianggang
supporting information, p. 16067 - 16076 (2021/06/17)
Unlike amyloid aggregates, amorphous protein aggregates with no defined structures have been challenging to target and detect in a complex cellular milieu. In this study, we rationally designed sensors of amorphous protein aggregation from aggregation-induced-emission probes (AIEgens). Utilizing dicyanoisophorone as a model AIEgen scaffold, we first sensitized the fluorescence of AIEgens to a nonpolar and viscous environment mimicking the interior of amorphous aggregated proteins. We identified a generally applicable moiety (dimethylaminophenylene) for selective binding and fluorescence enhancement. Regulation of the electron-withdrawing groups tuned the emission wavelength while retaining selective detection. Finally, we utilized the optimized probe to systematically image aggregated proteome upon proteostasis network regulation. Overall, we present a rational approach to develop amorphous protein aggregation sensors from AIEgens with controllable sensitivity, spectral coverage, and cellular performance.
Combination of N-Arylstilbazolium Organic Nonlinear Optical Chromophores with Iodoargentates: Structural Diversities and Optical Properties
Wang, Yu-Kang,Zhao, Li-Ming,Fu, Yu-Qing,Chen, Zhao,Lin, Xiao-Yan,Wang, Dao-Hua,Li, Yi,Li, Hao-Hong,Chen, Zhi-Rong
, p. 3827 - 3840 (2018/06/11)
A combination of N-arylstilbazolium organic nonlinear optical chromophores with iodoargentates results in five new hybrids, i.e., [(DAST)(Ag2I3)]n (1), [(DMAQS)(Ag2I3)]n (2), [(DPAS)(Ag2I3)]n (3), [(DPTAS)2(Ag5I7)]n (4), and [(CEMAS)2(Ag5I7)]n (5). Among them, the former four are centrosymmetric, and 5 is non-centrosymmetrical (space group Pna21) with the introduction of a cyano group in an organic chromophore. The (Ag5I7)n2n- chains in 4 and 5 are special, in which that of 4 is constructed from Ag5I10 building blocks with a μ6-I σ-bonding to six Ag ions, and that in 5 is the connection of a cubane-like Ag4I4 core with bridged AgI4 tetrahedra. UV/vis/near-IR adsorptions and near-IR photoluminescences have been observed. All the organic chromophores are stacked as head-to-tail arrangements, resulting in second harmonic generation (SHG) inactive in 1-4. But 5 is SHG active without J-aggregation of organic chromophore, whose symmetry break was driven by the formation of hydrogen bonds around the cyano group. The SHG activity of 5 originates from the polarizations of the asymmetric contribution of Ag5I94- unit mixing with non-centrosymmetrical (CEMAS)22+ pair. Theoretical calculations were carried out to disclose their electronic structures.
Synthesis, Crystal Structures, and Photophysical Properties Investigations of Two New Pyridinium Complexes Containing [Sm(TTA)4]- and [Eu(TTA)4]-
Zhang, Guo-Cui,Li, Dan-Dan,Kong, Ming,Su, Jian,Zhou, Hong-Ping,Wu, Jie-Ying,Tian, Yu-Peng
, p. 1254 - 1259 (2016/03/30)
Two new lanthanide(III) complexes were designed and synthesized: DAS[M(TTA)4]-, (M = Sm [1], M = Eu [2]), each of them contained one trans-4-[4'-(N, N-dimethylamino)styryl]-N-methyl pyridinium (DAS) cationic moiety, four 2-thenoyltrifluoroacetone anions (TTA-), and one cationic lanthanide(III). Herein, the structures were confirmed by single-crystal X-ray diffraction analysis. The results revealed that the central lanthanide(III) atom was fashionable eight-coordinated with square-antiprismatic coordination environment. Meanwhile, the photophysical properties of 1 and 2 were investigated by fluorescence spectra. It was proposed that there was an antenna effect and the energy transfer took place from the DAS cationic moiety to lanthanide(III) ions.
