95904-67-9Relevant academic research and scientific papers
A CONVENIENT METHOD FOR THE PREPARATION OF 3-TRIMETHYLSILYL-2,5-DIHYDROFURANS AND THEIR CONVERSION TO FURANS
Sato, Fumie,Kanbara, Hiroshi,Tanaka, Youichi
, p. 5063 - 5066 (1984)
Hydromagnesiation of 3-trimethylsilyl-2-propyn-1-ol (1) followed by reaction with aldehydes or ketones affords (E)-3-trimethylsilyl-2-alken-1,4-diols (2), which can be readily dehydrated to 3-trimethylsilyl-2,5-dihydrofurans (3) by treatment with BF3OEt2.The compounds 3 are converted to furans (5) by epoxidation and subsequent treatment with H2SO4.
