959042-54-7Relevant academic research and scientific papers
Base-Controlled Diastereoselective Synthesis of Either anti- or syn-β-Aminonitriles
Anderson, James C.,Campbell, Ian B.,Campos, Sebastien,Rundell, Christopher D.,Shannon, Jonathan,Tizzard, Graham J.
, p. 1918 - 1921 (2017)
Deprotonation of secondary alkane nitriles with nBuLi and addition to aryl imines gives kinetic anti-β-aminonitriles. Use of LHMDS allows reversible protonation of the reaction intermediate to give syn-β-aminonitriles. The pure diastereosiomers can be iso
Product-catalyzed addition of alkyl nitriles to unactivated imines promoted by sodium aryloxide/ethyl(trimethylsilyl)acetate (ETSA) combination
Poisson, Thomas,Gembus, Vincent,Oudeyer, Sylvain,Marsais, Francis,Levacher, Vincent
supporting information; experimental part, p. 3516 - 3519 (2009/09/30)
The first transition-metal-free addition of alkyl nitriles to unactivated imines was developed using a catalytic combination of 4-MeOC6H 4ONa and TMSCH2CO2Et to promote the reaction. The corresponding β-amino ni
