959162-95-9Relevant academic research and scientific papers
Synthesis and biological evaluation of potential bisubstrate inhibitors of protein farnesyltransferase. Design and synthesis of functionalized imidazoles
De Figueiredo, Renata Marcia,Coudray, Laetitia,Dubois, Joelle
, p. 3299 - 3309 (2008/09/20)
A novel series of compounds, derived from 2,5-functionalized imidazoles, have been synthesized as potential bisubstrate inhibitors of protein farnesyltransferase (FTase) using structure-based design. These compounds have a 1,4-diacid chain and a tripeptid
