959251-11-7

Basic information

• Product Name: 4-Fluoro-3-(phenylmethoxy)benzenemethanol
• Synonyms: 4-Fluoro-3-(phenylmethoxy)benzenemethanol
• CAS NO: 959251-11-7
• Molecular Formula: C₁₄H₁₃FO₂
• Molecular Weight: 232.2502232
• Mol File: 959251-11-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Fluoro-3-(phenylmethoxy)benzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-3-(phenylmethoxy)benzenemethanol(959251-11-7)
• EPA Substance Registry System: 4-Fluoro-3-(phenylmethoxy)benzenemethanol(959251-11-7)

Safety Data

• Hazardous Substances Data: 959251-11-7(Hazardous Substances Data)

Upstream product

• 1246458-41-2 methyl 3-benzyloxy-4-fluorobenzoate 
• 103438-91-1 3-benzyloxy-4-fluorobenzaldehyde 

Downstream Products

• 103438-91-1 3-benzyloxy-4-fluorobenzaldehyde 
• 1426298-30-7 C₁₅H₁₂FNO 
• 123926-57-8 3-benzyloxy-4-fluorobenzyl bromide 
• 1426298-32-9 C₁₉H₂₈FN₃O₅ 
• 128495-64-7 2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide 
• 1426298-31-8 C₁₅H₁₆FNO 

Relevant articles and documents

Synthesis and bioevaluation of [18F]4-fluoro-m- hydroxyphenethylguanidine ([18F]4F-MHPG): A novel radiotracer for quantitative PET studies of cardiac sympathetic innervation

A new cardiac sympathetic nerve imaging agent, [18F]4-fluoro-m- hydroxyphenethylguanidine ([18F]4F-MHPG), was synthesized and evaluated. The radiosynthetic intermediate [18F]4-fluoro-m-tyramine ([18F]4F-MTA) was prepared and then sequentially reacted with cyanogen bromide and NH4Br/NH4OH to afford [ 18F]4F-MHPG. Initial bioevaluations of [18F]4F-MHPG (biodistribution studies in rats and kinetic studies in the isolated rat heart) were similar to results previously reported for the carbon-11 labeled analog [11C]4F-MHPG. The neuronal uptake rate of [18F]4F-MHPG into the isolated rat heart was 0.68 ml/min/g wet and its retention time in sympathetic neurons was very long (T1/2 >13 h). A PET imaging study in a nonhuman primate with [18F]4F-MHPG provided high quality images of the heart, with heart-to-blood ratios at 80-90 min after injection of 5-to-1. These initial kinetic and imaging studies of [18F]4F-MHPG suggest that this radiotracer may allow for more accurate quantification of regional cardiac sympathetic nerve density than is currently possible with existing neuronal imaging agents.

N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS

Disclosed herein are substantially pure forms of the compounds of Formula (I), (II), (III), (IV) and (V), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer or ester thereof. Also disclosed are methods of inhibiting an activity of a serotonin receptor, methods inhibiting an activation of a serotonin receptor, and methods of alleviating or treating various disease conditions and side effects.