95927-52-9

Upstream product

• 54760-14-4 N-(3-cyano-4-phenyl-1H-pyrrol-2-yl)acetamide 
• 1060815-92-0 4-chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1527475-96-2 4-chloro-5-iodo-2-methyl-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 95963-08-9 2-Methyl-5-phenyl-N-propyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95927-60-9 N-(4-Fluorophenyl)-2-methyl-5-phenyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95927-62-1 N-(2,6-dimethylphenyl)-2-methyl-5-phenyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95927-42-7 N,N,2-Trimethyl-5-phenyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95963-09-0 N,N-Diethyl-2-methyl-5-phenyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95927-59-6 2-Methyl-N,5-diphenyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95927-43-8 N,N-diethyl-2-methyl-3-(2-methyl-5-phenyl-7H-pyrrolo<2,3-d>pyrimidin-4-yl)-5-phenyl-3H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 95927-61-0 2-Methyl-N-(3-methylphenyl)-5-phenyl-7H-pyrrolo<2,3-d>pyrimidin-4-amine 

Relevant academic research and scientific papers

Synthesis of 2,6-Substituted 7-(Het)aryl-7-deazapurine Nucleobases (2,4-Disubstituted 5-(Het)aryl-pyrrolo[2,3- d ]pyrimidines)

A series of 7-(het)aryl-7-deazapurine nucleobases (5-[(het)aryl]-2,4-disubstituted 7 H -pyrrolo[2,3- d ]pyrimidines) bearing NH 2, OMe, SMe, or Me groups at position 6 and H, NH 2, or Me at position 2 were prepared by the aqueous Suzuki-Miyaura cross-coupling reactions from SEM-protected 7-iodo-7-deazapurines with (het)arylboronic acids followed by deprotection. The 6-methoxy derivatives were further transformed into 7-deazahypoxanthines or 7-deazaguanines by O -demethylation reactions. Unlike their ribonucleoside counterparts, the 7-deazapurine nucleobases did not exert any significant cytostatic or antiviral effects.