959285-73-5Relevant academic research and scientific papers
Iridium-catalyzed enantioselective hydroalkynylation via alkene isomerization
Zhang, Wen-Wen,Li, Bi-Jie
supporting information, (2021/05/10)
An iridium-catalyzed enantioselective alkynylation of methylene C–H bonds γ to the amide group is developed. The reaction proceeds through alkene isomerization followed by regioselective hydroalkynylation. This method provides rapid access to a wide range of stereodefined alkynylated compounds in good yields and good enantioselectivities.
Cobalt- versus ruthenium-catalyzed Alder-ene reaction for the synthesis of credneramide A and B
Erver, Florian,Hilt, Gerhard
experimental part, p. 5215 - 5219 (2012/07/16)
The first synthesis of the natural products credneramide A and B was accomplished by utilizing Alder-ene reactions between a terminal alkene and an internal alkyne to generate the rather uncommon 1,4-diene substructure of these compounds. Moreover, two different short linear sequences toward these targets are evaluated using either a cobalt-catalyzed Alder-ene reaction of 1-chloropent-1-yne or a ruthenium-catalyzed Alder-ene reaction of 1-trimethylsilyl-1-pentyne with 5-hexenoic acid derivatives in the key step transformation. In addition, saponification of the primary Alder-ene product derived from the cobalt-catalyzed Alder-ene reaction led to credneric acid, the biological precursor of both natural products.
Amide-forming ligation of acyltrifluoroborates and hydroxylamines in water
Dumas, Aaron M.,Molander, Gary A.,Bode, Jeffrey W.
supporting information; experimental part, p. 5683 - 5686 (2012/07/01)
Come together, right now: Acyltrifluoroborates and O-benzoyl hydroxylamines come together to form amides in water (see scheme). The ligations are complete within minutes at room temperature and do not require any reagents or catalysts. The reaction has a broad substrate scope and tolerates unprotected functional groups. Copyright
Aluminium triflate-catalysed regioselective cycloisomerisation of non-activated unsaturated oximes
Chaminade, Xavier,Chiba, Shunsuke,Narasaka, Koichi,Dunach, Elisabet
, p. 2384 - 2387 (2008/09/18)
A novel cycloisomerisation of oximes bearing non-activated C-C double bonds occurs in an Al(III)-catalysed reaction. This process leads to 5-, 6- and 7-membered ring oxygen and nitrogen-containing heterocycles in good yields.
