95931-48-9

Upstream product

• 95931-47-8 Methyl 2-acetyl-5-amino-4-cyano-3-(3-nitrophenyl)-5-oxopentanoate 
• 55629-53-3 2-Cyano-3-(3-nitrophenyl)-2-propenamide 
• 99-61-6 3-nitro-benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 107-91-5 cyanoacetic acid amide 
• 109-77-3 malononitrile 

Downstream Products

• 40034-66-0 3-(2-Methyl-pyridin-4-yl)-phenylamine 
• 57976-37-1 3-(2-Methoxy-6-methyl-pyridin-4-yl)-phenylamine 
• 95970-38-0 2-Chloro-6-methyl-4-(3-nitro-phenyl)-pyridine 
• 40034-95-5 6-Methyl-4-(3-nitrophenyl)-2(1H)-pyridinone 
• 57976-36-0 2-Methoxy-6-methyl-4-(3-nitrophenyl)pyridine 
• 95931-45-6 Methyl 5-cyano-1,6-dihydro-2-methyl-4-(3-nitrophenyl)-6-oxo-3-pyridinecarboxylate 

Relevant academic research and scientific papers

Chem-grafted Zn-SSA as an Efficient Heterogeneous Catalyst to Synthesize 2-Pyridinones

Abstract: Chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be a high efficient heterogeneous catalyst to solve this problem. Under Zn–SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production. Graphical Abstract: Improving chemo-selectivity is always a hard problem in preparing 2-pyridinones. Silica sulfuric acid (SSA) modified with zinc chloride (Zn–SSA) was found to be efficient heterogeneous catalyst to solve this problem. Under Zn-SSA and solvent-free conditions, the one-pot cyclocondensation of 1,3-dicarbonyl compounds, malononitrile and arylaldehydes to afford 2-pyridinones was conveniently implemented. The heterogeneous reaction was much efficient and promising in pharmaceutical study and industrial production.[Figure not available: see fulltext.]

Imidazole-catalyzed three-component cascade reaction for the facile synthesis of highly substituted 3,4-dihydropyridin-2-one derivatives

A novel one-pot protocol for the synthesis of valuable 3,4-dihydropyridin- 2-ones from the condensation of aldehyde with cyanoacetamide and 1,3-dicarbonyl compounds in the presence of imidazole was developed. A series of aldehydes and 1,3-dicarbonyl compounds were employed to examine the scope of substrates for this protocol. This reaction proceeded through the formation of one ring and four new bonds (two Ci￡C, one Ci￡N, one Ci￡C) via the sequence involving Knoevenagel condensation, Michael addition and intramolecular cyclization with moderate to excellent yields. All new compounds were characterized by IR, 1H NMR, 13C NMR and HRMS. Copyright