959415-86-2Relevant academic research and scientific papers
Enantioselective supramolecular catalysis induced by remote chiral diols
Van Leeuwen, Piet W. N. M.,Rivillo, David,Raynal, Matthieu,Freixa, Zoraida
, p. 18562 - 18565 (2012/01/31)
A new method of creating libraries of chiral diphosphines is presented. Supramolecular coordination compounds based on Ti, Rh, achiral ditopic ligands, and chiral diols were synthesized by in situ mixing and used as catalysts in the asymmetric hydrogenation of (Z)-methyl 2-acetamido-3-phenylacrylate, giving ee's of up to 92%. The ditopic ligands contain a Schiff base that coordinates to the assembly metal Ti and a phosphine as a ligand for Rh. Chirality is introduced by coordination of the chiral diols to Ti. The controlling chiral center and the substrate are separated by as much as 13 A.
