959425-58-2Relevant academic research and scientific papers
Modification and biological evaluation of novel 4-hydroxy-pyrone derivatives as non-peptidic HIV-1 protease inhibitors
He, Meizi,Yang, Ning,Sun, Chunlai,Yao, Xiaojian,Yang, Ming
, p. 200 - 209 (2012/03/10)
In this study, we have modified 4-hydroxy-pyran-2-ones, especially introduced heteroatoms (S or O) into the substituents, and detected their interactions with the binding pockets of HIV-1 protease (PR). The results indicated that the ethoxyl groups at C-2
