959432-42-9Relevant articles and documents
Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy
Verhoest, Patrick R.,Proulx-Lafrance, Caroline,Corman, Michael,Chenard, Lois,Helal, Christopher J.,Hou, Xinjun,Kleiman, Robin,Liu, Shenping,Marr, Eric,Menniti, Frank S.,Schmidt, Christopher J.,Vanase-Frawley, Michelle,Schmidt, Anne W.,Williams, Robert D.,Nelson, Frederick R.,Fonseca, Kari R.,Liras, Spiros
supporting information; experimental part, p. 7946 - 7949 (2010/08/03)
By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.