959509-80-9

Upstream product

• 122-00-9 para-methylacetophenone 
• 39757-29-4 methyl 2,4-dioxo-4-p-tolylbutanoate 
• 192701-73-8 methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate 
• 1375158-52-3 methyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 

Downstream Products

• 1375158-58-9 1-benzyl-3-(4-methylphenyl)-N'-quinolin-2-yl-1H-pyrazole-5-carbohydrazide 
• 1375158-54-5 ethyl 1-{[1-benzyl-3-(4-methylphenyl)-1H-pyrazol-5-yl]carbonyl}piperidine-4-carboxylate 
• 1375158-55-6 1-{[1-benzyl-3-(4-methylphenyl)-1H-pyrazol-5-yl]carbonyl}-4-(4-tert-butylbenzyl)piperazine 
• 1375158-56-7 1-{[1-benzyl-3-(4-methylphenyl)-1H-pyrazol-5-yl]carbonyl}-4-(2,3,4-trimethoxybenzyl)piperazine 
• 1375158-57-8 1-benzyl-3-(4-methylphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide 
• 1375158-59-0 4-tert-butylphenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-60-3 4-(isopropyl)phenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-61-4 4-(heptyloxy)phenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-62-5 4-[4-(trifluoromethyl)phenoxy]phenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 
• 1375158-63-6 4-(1H-imidazol-1-yl)phenyl 1-benzyl-3-(4-methylphenyl)-1H-pyrazole-5-carboxylate 

Relevant academic research and scientific papers

Synthesis and evaluation of analgesic, anti-inflammatory, and anticancer activities of new pyrazole-3(5)-carboxylic acid derivatives

In this article, we synthesized a series of novel 1-benzyl-5(3)-p-tolyl-1H- pyrazole-3(5)-carboxylic acid derivatives and characterized by IR, 1H NMR, and mass spectroscopy. Compounds were evaluated for their in vivo analgesic and anti-inflammatory activity using the p-benzoquinone-induced writhing test and the carrageenan-induced paw edema model, respectively. Out of 14 compounds tested, 7a, 7c, 7e, 7f, 7i, 8a-b, and 8f-g exhibited potent analgesic and/or anti-inflammatory activity as compared to reference drugs aspirin and indomethacin. Anticancer activity of these compounds was assessed against five cancer cell lines with the MTT assay (HL-60, human promyelocytic leukemia cells; HeLa, human cervical cancer cells; Raji, human B lymphocyte cell line; MCF7, human breast adenocarcinoma cell line; MDA-MB-231, estrogen-independent human breast cancer cell line). Compounds 7a, 8a, and 8b with high anti-inflammatory activity, and also 7d and 7j with mild anti-inflammatory activity exhibited promising anticancer activity against some selected cell lines.