959551-10-1 Usage
Description
NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, which serves as a potentially powerful tool for exploring the cell physiology of PI5P4Ks. It is also used as a reagent in the synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amines, which are potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against non-small cell lung cancer.
Uses
Used in Pharmaceutical Research:
NIH-12848 is used as a PI5P4Kγ inhibitor for studying the cell physiology of PI5P4Ks, which can provide insights into the development of new therapeutic strategies for various diseases.
Used in Anticancer Drug Development:
NIH-12848 is used as a reagent in the synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amines, which are potent USP1/UAF1 deubiquitinase inhibitors. These inhibitors exhibit anticancer activity against non-small cell lung cancer, making NIH-12848 a valuable tool in the development of new cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 959551-10-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,9,5,5 and 1 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 959551-10:
(8*9)+(7*5)+(6*9)+(5*5)+(4*5)+(3*1)+(2*1)+(1*0)=211
211 % 10 = 1
So 959551-10-1 is a valid CAS Registry Number.
959551-10-1Relevant articles and documents
Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γinhibitors with a Non-ATP-competitive, Allosteric Binding Mode
Andrews, Stephen P.,Boffey, Helen K.,Clarke, Jonathan H.,Duce, James,Edwards, Simon,Green, Christopher,Howard, Tina,Ogg, Derek,Romero, Tamara,Rooney, Timothy P. C.,Scott, Duncan E.,Skidmore, John,Willems, Henriette M. G.,Winpenny, David
, (2022/02/25)
Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are emerging as attractive therapeutic targets in diseases, such as cancer, immunological disorders, and neurodegeneration, owing to their central role in regulating cell signaling pathways that are eit
