959618-94-1

Upstream product

• 6652-32-0 3,5-dimethoxybenzylchloride 
• 41979-39-9 4-piperidone hydrochloride 
• 877-88-3 3,5-dimethoxybenzyl bromide 
• 40064-34-4 piperidine-4,4-diol hydrochloride 

Downstream Products

• 959618-97-4 C₃₃H₄₅N₃O₇ 
• 959618-96-3 C₁₉H₂₇N₃O₅ 
• 959618-95-2 C₁₈H₂₇N₃O₃ 
• 916157-43-2 C₂₉H₃₉N₃O₈ 

Relevant academic research and scientific papers

N - substituted - 3, 5 - di (2 - (trifluoromethyl) benzylidene) piperidine -4 - ketone derivative and its preparation method and application

The invention discloses an N-substituted-3,5-bis(2-trifluoromethyl)benzal)piperidine-4-one derivative used for resisting inflammation, a preparation method and an application thereof and belongs to the field of medicinal chemistry. In the method, the target compound, N-substituted-3,5-bis(2-trifluoromethyl)benzal)piperidine-4-one derivative, is synthesized through a condensation reaction with N-substituted piperidone and o-trifluoromethyl benzaldehyde and the like as raw materials. The N-substituted-3,5-bis(2-trifluoromethyl)benzal)piperidine-4-one derivative has a certain inhibition effect on an experiment cell and shows an excellent anti-inflammation activity.

Synthesis and Evaluation of Anti-inflammatory N-Substituted 3,5-Bis(2-(trifluoromethyl)benzylidene)piperidin-4-ones

A total of 24 N-substituted 3,5-bis(2-(trifluoromethyl)benzylidene)piperidin-4-one derivatives were synthesized via aldol condensation, and their anti-inflammatory activities were evaluated. These compounds were found to have no significant cytotoxicity a

METHOD OF MAKING IMIDAZOAZEPINONE COMPOUNDS

A method of making a compound of Formula I: is carried out by (a) providing a compound of Formula (II) or (III): wherein ring A is C3-14 aryl or C3-14 heteroaryl such as phenyl or furanyl, and then (b) combining the compound of Formula (II) or (III) with an acid to produce a compound of Formula I.

Synthesis and potent antileukemic activities of 10-benzyl-9(10H)-acridinones

A novel series of 10-benzyl-9(10H)-acridinones and 1-benzyl-4-piperidones were synthesized and tested for their in vitro antitumor activities against CCRF-CEM cells. Assay-based antiproliferative activity study using CCRF-CEM cell lines revealed that the acridone group and the substitution pattern on the benzene unit had significant effect on cytotoxicity of this series of compounds, among which 10-(3,5-dimethoxy)benzyl-9(10H)-acridinone (3b) was found to be the most active compound with IC50 at about 0.7 μM. Compound 3b was also found to have antiproliferative activity against two other human leukemic cell lines K562 and HL60 using the MTT assay. The antitumor effect of 3b is believed to be due to the induction of apoptosis, which is further confirmed by PI (Propidium iodide) staining and Annexin V-FITC/PI staining assay using flow cytometry analysis.

IMIDAZOAZEPHINONE COMPOUNDS

The invention relates to compounds of formula (I): along with pharmaceutical compositions containing the same and methods of use thereof.