959626-45-0

Basic information

• Product Name: N-[2,5-bis(1-piperidyl)phenyl]-5-cyano-furan-2-carboxamide
• Synonyms: 2-furancarboxamide, 5-cyano-N-(2,5-di-1-piperidinylphenyl)-; 5-cyano-N-[2,5-di(piperidin-1-yl)phenyl]furan-2-carboxamide
• CAS NO: 959626-45-0
• Molecular Formula: C₂₂H₂₆N₄O₂
• Molecular Weight: 378.4674
• Mol File: 959626-45-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 530.5°C at 760 mmHg
• Flash Point: 274.6°C
• Density: 1.26g/cm³
• Vapor Pressure: 2.45E-11mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: N-[2,5-bis(1-piperidyl)phenyl]-5-cyano-furan-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2,5-bis(1-piperidyl)phenyl]-5-cyano-furan-2-carboxamide(959626-45-0)
• EPA Substance Registry System: N-[2,5-bis(1-piperidyl)phenyl]-5-cyano-furan-2-carboxamide(959626-45-0)

Safety Data

• Hazardous Substances Data: 959626-45-0(Hazardous Substances Data)

Upstream product

• 791587-69-4 5-cyanofuran-2-carbonyl chloride 

Relevant articles and documents

Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents

A series of 2′-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 μM) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 μM) and as such, serves as a lead candidate for further optimization studies.