959705-17-0

Basic information

• Product Name: bis(2,3-bis(tert-butylmethylphosphino)quinoxaline)aurate(I) chloride
• Synonyms: bis(2,3-bis(tert-butylmethylphosphino)quinoxaline)aurate(I) chloride
• CAS NO: 959705-17-0
• Molecular Weight: 901.182
• Mol File: 959705-17-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: bis(2,3-bis(tert-butylmethylphosphino)quinoxaline)aurate(I) chloride(CAS DataBase Reference)
• NIST Chemistry Reference: bis(2,3-bis(tert-butylmethylphosphino)quinoxaline)aurate(I) chloride(959705-17-0)
• EPA Substance Registry System: bis(2,3-bis(tert-butylmethylphosphino)quinoxaline)aurate(I) chloride(959705-17-0)

Safety Data

• Hazardous Substances Data: 959705-17-0(Hazardous Substances Data)

Upstream product

• 959705-18-1 (R,R)-(-)-2,3-bis(tert-butylmethylphosphino)quinoxaline 
• 866081-62-1 (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline 
• 205521-54-6 cis-[(2-benzoylpyridine)AuCl₂] 

Relevant articles and documents

METHOD FOR PRODUCING OPTICALLY ACTIVE 2, 3-BISPHOSPHINOPYRAZINE DERIVATIVE AND METHOD FOR PRODUCING OPTICALLY ACTIVE PHOSPHINE TRANSITION METAL COMPLEX

In the method for producing an optically active 2,3-bisphosphinopyrazine derivative of the present invention, an optically active 2,3-bisphosphinopyrazine derivative represented by the following formula (3) is produced by the step of: preparing solution A containing 2,3-dihalogenopyrazine represented by the following formula (1) and a carboxylic acid amide coordinating solvent, lithiating an optically active R- or S-isomer of a hydrogen-phosphine borane compound represented by the following formula (2) to give a lithiated phosphine borane compound; adding solution B containing the lithiated phosphine borane compound to the solution A to perform an aromatic nucleophilic substitution reaction; and then performing a deboranation reaction. (For symbols in the formulas, see the description.)

METHOD FOR PRODUCING 2,3-BISPHOSPHINOPYRAZINE DERIVATIVE, AND METHOD FOR PRODUCING PHOSPHINE TRANSITION METAL COMPLEX

There is provided a method for producing a 2,3-bisphosphinopyrazine derivative, the method comprising a first step of adding a base to a liquid comprising: 2,3-dihalogenopyrazine represented by the following general formula (1); a hydrogen-phosphine borane compound represented by the following general formula (2); and a deboranating agent, and allowing the resultant to react to thereby obtain the 2,3-bisphosphinopyrazine derivative represented by the following general formula (3). According to the present invention, a method for producing the industrially advantageous 2,3-bisphosphinopyrazine derivative can be provided.

Anticancer agent composition

Provided is an anti-cancer agent composition exhibiting excellent solubility and exerting high anti-cancer activity while exhibiting low toxicity. An anti-cancer composition characterized by containing a cyclodextrin compound and a phosphine transition metal complex represented by general formula (1). (In the formula, R1 and R2 represent a linear or branched alkyl group, a cycloalkyl group, a cycloalkyl group having a substituent, an adamantyl group, a phenyl group, or a phenyl group having a substituent, have a carbon number between 1 and 10, and may represent the same group or different groups. R3 and R4 represent a hydrogen atom or a linear or branched alkyl group, have a carbon number between 1 and 6, and may represent the same group or different groups. R3 and R4 may form a saturated or unsaturated ring by bonding to one another and said saturated or unsaturated ring may have a substituent. M represents a transition metal atom selected from among gold, copper, and silver. X- represents an anion.)