959713-53-2Relevant academic research and scientific papers
Identification of a series of benzoxazoles as potent 5-HT6 ligands
Liu, Kevin G.,Lo, Jennifer R.,Comery, Thomas A.,Zhang, Guo Ming,Zhang, Jean Y.,Kowal, Dianne M.,Smith, Deborah L.,Di, Li,Kerns, Edward H.,Schechter, Lee E.,Robichaud, Albert J.
scheme or table, p. 1115 - 1117 (2009/08/07)
As part of our continuing efforts to identify therapeutics for CNS diseases such as schizophrenia and Alzheimer's disease (AD), we have been focused on the 5-HT6 receptor in order to identify potent and selective ligands as a potential treatment for cognitive dysfunction. Herein we report the identification of a novel series of benzoxazole derivatives as potent 5-HT6 ligands. The synthesis and detailed SAR of this class of compounds are reported. The compounds have been shown to be full antagonists in a cyclic AMP functional assay.
Benzoxazole and benzothiazole derivatives as 5-hydroxytryptamine-6 ligands
-
Page/Page column 11, (2008/06/13)
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
