959771-44-9

Upstream product

• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 867338-58-7 N-(2,4-dimethoxybenzyl)prop-2-yn-1-amine 
• 634-97-9 pyrrole-2-carboxyl acid 
• 90471-24-2 2,5-dioxopyrrolidin-1-yl 1H-pyrrole-2-carboxylate 

Downstream Products

• 959771-45-0 N-[3-(3-cyano-4-fluorophenyl)prop-2-yn-1-yl]-N-(2,4-dimethoxybenzyl)-1H-pyrrole-2-carboxamide 
• 1111085-74-5 C₁₇H₁₈N₂O₃ 
• 1111085-73-4 C₁₇H₁₈N₂O₃ 
• 1111085-33-6 C₂₃H₂₂N₂O₃ 
• 1111085-70-1 C₂₃H₂₁FN₂O₃ 
• 1111085-69-8 C₂₄H₂₄N₂O₄ 
• 1111085-68-7 C₂₄H₂₄N₂O₄ 
• 1111085-71-2 C₂₄H₂₁N₃O₃ 
• 959771-46-1 4-{[2-(2,4-dimethoxybenzyl)-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl]methyl}-2-fluorobenzonitrile 

Relevant academic research and scientific papers

A novel base-mediated intramolecular hydroamination to build fused heteroaryl pyrazinones

Functionalized fused heteroaryl pyrazinones were built up through a novel DBU-catalyzed intramolecular hydroamination reaction of aryl(prop-2-yn-1-yl)-1H-heteroaryl-2-carboxamides. The nucleophilic addition afforded three isomers; two with an exo-cyclic d

PYRROLO[1,2-A]PYRAZIN-1(2H)-ONE AND PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE(PARP)

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.