959780-14-4

Basic information

• Product Name: [bis(3-(hexadecyloxy)propoxy)phosphoryl]methyl tosylate
• Synonyms: [bis(3-(hexadecyloxy)propoxy)phosphoryl]methyl tosylate
• CAS NO: 959780-14-4
• Molecular Weight: 831.232
• Mol File: 959780-14-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [bis(3-(hexadecyloxy)propoxy)phosphoryl]methyl tosylate(CAS DataBase Reference)
• NIST Chemistry Reference: [bis(3-(hexadecyloxy)propoxy)phosphoryl]methyl tosylate(959780-14-4)
• EPA Substance Registry System: [bis(3-(hexadecyloxy)propoxy)phosphoryl]methyl tosylate(959780-14-4)

Safety Data

• Hazardous Substances Data: 959780-14-4(Hazardous Substances Data)

Upstream product

• 161760-09-4 {[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid 
• 35717-98-7 bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 864068-45-1 {[3-(hexadecyloxy)propoxy](hydroxy)phosphoryl}methyl tosylate 

Relevant articles and documents

Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety

Hexadecyloxypropyl esters of acyclic nucleoside phosphonates containing guanine (G) or hypoxanthine (Hx) and a (S)-[3-hydroxy-2-(phosphonomethoxy) propyl] [(S)-HPMP] or 2-(2-phosphonoethoxy)ethyl (PEE) acyclic moiety have been prepared. The activity of the prodrugs was evaluated in vitro against different virus families. Whereas ester derivatives of PEEHx and (S)-HPMPHx were antivirally inactive, monoesters of PEEG, and mono- and diesters of (S)-HPMPG showed pronounced antiviral activity against vaccinia virus and/or herpesviruses. Monoesters of (S)-HPMPG emerged as the most potent and selective derivatives against these DNA viruses. None of the compounds were inhibitory against RNA viruses and retroviruses. Crown Copyright